A study of emergency cainvolving victims ofevere brain trauma is to beperformed in this area.Regions Hospital is conducting a research studyto learn if either of two strategies for monitoringand treating patients with severe traumatic braininjury in the intensive care unit (ICU) is more likelyto help them get better. Because head injury isa life threatening condition requiring immediatetreatment, some patients will be enrolled withoutconsent if family member or representative is notrapidly available. Before the study starts, we willconsult with the community. We welcome yourfeedback and questions. For more information orto decline participation in this study, please visitboost3trial.org or contact our study staff at651-254-5316Primary Investigator: Dr. Michael Brogan, MDStudy Coordinator: Jenny KoopsBO-OST3 A study of emergency ca involving victims of evere brain trauma is to be performed in this area. Regions Hospital is conducting a research study to learn if either of two strategies for monitoring and treating patients with severe traumatic brain injury in the intensive care unit (ICU) is more likely to help them get better. Because head injury is a life threatening condition requiring immediate treatment, some patients will be enrolled without consent if family member or representative is not rapidly available. Before the study starts, we will consult with the community. We welcome your feedback and questions. For more information or to decline participation in this study, please visit boost3trial.org or contact our study staff at 651-254-5316 Primary Investigator: Dr. Michael Brogan, MD Study Coordinator: Jenny Koops BO-OST3

Date: July 13, 2019

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A study of emergency ca involving victims of evere brain trauma is to be performed in this area. Regions Hospital is conducting a research study to learn if either of two strategies for monitoring and treating patients with severe traumatic brain injury in the intensive care unit (ICU) is more likely to help them get better. Because head injury is a life threatening condition requiring immediate treatment, some patients will be enrolled without consent if family member or representative is not rapidly available. Before the study starts, we will consult with the community. We welcome your feedback and questions. For more information or to decline participation in this study, please visit boost3trial.org or contact our study staff at 651-254-5316 Primary Investigator: Dr. Michael Brogan, MD Study Coordinator: Jenny Koops BO-OST3 A study of emergency ca involving victims of evere brain trauma is to be performed in this area. Regions Hospital is conducting a research study to learn if either of two strategies for monitoring and treating patients with severe traumatic brain injury in the intensive care unit (ICU) is more likely to help them get better. Because head injury is a life threatening condition requiring immediate treatment, some patients will be enrolled without consent if family member or representative is not rapidly available. Before the study starts, we will consult with the community. We welcome your feedback and questions. For more information or to decline participation in this study, please visit boost3trial.org or contact our study staff at 651-254-5316 Primary Investigator: Dr. Michael Brogan, MD Study Coordinator: Jenny Koops BO-OST3